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Preclinical and translational studies indicate that multi-receptor agonism can influence liver fat measurements, hepatic triglyceride handling, cholesterol metabolism, and biochemical markers associated with liver function

Gradual dose titration can minimise side effects

Therefore, the aim of this study was to explore the commonality and specificity of the pharmacodynamic effects and pharmacological mechanisms of caffeine and EGCG on NASH mice, which were fed with a high-trans fatty acid/high-carbohydrate (HFHC) diet

J Clin Invest 2014;124:4473-88.ArticlePubMedPMC 58

Study: Glucagon-like peptide-1 receptor agonists and risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study